#LOW AG RATIO PC#

All the hemostatic parameters correlated with cirrhosis severity (p< 0.05).Īt 12 months: 35 patients (28%) experienced a clinical decompensation, 23 (19%) died, 16 (13%) were transplanted.

Results: A pro-hemostatic imbalance was resumed by ADAMTS13/VWF:Ag of 0.21+/-0.14 and FVIII/PC of 6.0+/-6.5. The prognostic role of the hemostatic parameters was tested by logistic regression and expressed as risk of adverse outcome predicted by the model. Liver decompensations requiring hospitalization, death or transplantation were retrospectively collected and presented as cumulative risk at 12 months from baseline evaluation.

#LOW AG RATIO PC#

Hemostatic parameters measured at inclusion were VWF:Ag, ADAMTS13 activity, FVIII, FII, antithrombin, PC and were correlated with the severity of liver disease (Pearson coefficient). Main etiologies were virus/alcohol (40/60%). Low ADAMTS13/Von Willebrand Factor antigen (VWF:Ag) ratio and high factor VIII/protein C (FVIII/PC) mark platelet hyperaggregation and hypercoagulation, respectively.Īims: Our study aimed at exploring the association of such parameters with the severity of liver disease measured by the Child-Pugh, MELD, MELD-Na scores and their prognostic role on clinical outcome. Theme: Thrombotic Microangiopathies » Non HUS/TTP Microangiopathiesīackground: Hemostasis can be mechanism of liver damage in cirrhosis.

Low ag ratio